Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD, USA.
Andrology. 2013 Sep;1(5):741-8. doi: 10.1111/j.2047-2927.2013.00110.x. Epub 2013 Jul 10.
Infertility is a couple-based fecundity impairment, although population level research is largely based upon information reported by female partners. Of the few studies focusing on male partners, most focus on the utilization of infertility services rather than efforts to estimate the prevalence and determinants of infertility as reported by male partners. Data from a nationally representative sample of men aged 15-44 years who participated in the 2002 National Survey of Family Growth (NSFG) were used to estimate the prevalence of infertility and determinants of longer time-to-pregnancy (TTP) using the novel current duration (CD) approach. Using backward recurrence time parametric survival methods, we estimated infertility prevalence (TTP > 12 months) and time ratios (TR) associated with TTP as derived from males' reported CD of their pregnancy attempt. The estimated prevalence of infertility was 12.0% (95% CI: 7.0, 23.2). Longer TTP was associated with older male age (35-45 vs. 17-24 years) (TR: 2.49; 95% CI: 1.03, 6.03), biological childlessness (TR: 1.53; 95% CI: 1.07, 2.19) and lack of health insurance (TR: 1.73; 95% CI: 1.02, 2.94) after controlling for the differences in couples' age and other socioeconomic factors. The prevalence of infertility based on male reporting is consistent with estimates of infertility in the US found in prospective cohort studies and CD studies based on female reporting. Our findings suggest that male partners can reliably inform about couple infertility. Interventions and services aimed at reducing couple infertility should include attention to male factors associated with longer TTP identified in this study.
不孕是一种基于夫妻双方生育能力受损的情况,尽管人口水平的研究主要基于女性伴侣报告的信息。在为数不多的关注男性伴侣的研究中,大多数研究都集中在不孕不育服务的利用上,而不是努力估计男性伴侣报告的不孕不育的流行率和决定因素。本研究使用了来自全国代表性的 15-44 岁男性样本数据,这些男性参加了 2002 年全国家庭成长调查(NSFG),使用新颖的当前持续时间(CD)方法来估计不孕的流行率和导致妊娠时间延长(TTP)的决定因素。使用向后递归时间参数生存方法,我们根据男性报告的妊娠尝试 CD,估计了不孕流行率(TTP>12 个月)和与 TTP 相关的时间比(TR)。不孕的估计流行率为 12.0%(95%CI:7.0,23.2)。更长的 TTP 与男性年龄较大(35-45 岁与 17-24 岁)(TR:2.49;95%CI:1.03,6.03)、生物学无子女(TR:1.53;95%CI:1.07,2.19)和缺乏健康保险(TR:1.73;95%CI:1.02,2.94)相关,同时控制了夫妇年龄和其他社会经济因素的差异。基于男性报告的不孕流行率与前瞻性队列研究和基于女性报告的 CD 研究中发现的美国不孕流行率估计值一致。我们的研究结果表明,男性伴侣可以可靠地报告夫妻不孕情况。旨在减少夫妻不孕的干预和服务应包括关注本研究中确定的与更长 TTP 相关的男性因素。