Kalantar-Zadeh K, Kopple J D, Kamranpour N, Fogelman A M, Navab M
Harold Simmons Center for Kidney Disease Research and Epidemiology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
Kidney Int. 2007 Nov;72(9):1149-56. doi: 10.1038/sj.ki.5002491. Epub 2007 Aug 29.
Oxidative stress and cardiovascular disease are risk factor of patients with chronic kidney disease (CKD) on maintenance hemodialysis. We used the fluorescence of low-density lipoprotein as an index of its proinflammatory potential to examine any role that high-density lipoprotein (HDL) might have in promoting this effect. The total body fat of the patients was measured by means of near-infrared interactance and their quality of life by means of SF36 questionnaires. In 189 randomly selected patients, followed for 30 months, HDL was found to be significantly anti-inflammatory but with a large standard deviation. Fully 17% of the patients had a decidedly proinflammatory index along with inferior SF36 scores. The patients were divided into 10% increments of total body fat percentages up to 40%. HDL was found to be progressively proinflammatory the higher the body fat content. Patients with a higher HDL proinflammatory index had a higher 30-month adjusted hazard ratio for death than those whose HDL were seen to be anti-inflammatory. Our findings suggest an important role of inflammatory HDL in patients with CKD leading to poor outcome.
氧化应激和心血管疾病是维持性血液透析慢性肾脏病（CKD）患者的危险因素。我们将低密度脂蛋白的荧光作为其促炎潜能的指标，以研究高密度脂蛋白（HDL）在促进这种效应中可能发挥的任何作用。通过近红外交互作用测量患者的全身脂肪，并通过SF36问卷评估他们的生活质量。在189名随机选择的患者中，随访30个月，发现HDL具有显著的抗炎作用，但标准差较大。足足17%的患者具有明显的促炎指数以及较低的SF36评分。将患者按全身脂肪百分比以10%的增量进行分组，直至40%。发现身体脂肪含量越高，HDL的促炎作用越强。HDL促炎指数较高的患者比HDL具有抗炎作用的患者在30个月时的校正死亡风险比更高。我们的研究结果表明，促炎的HDL在导致CKD患者预后不良中起重要作用。
