一种基于模板的单胺氧化酶（MAO-N）催化反应记忆法及其在生物碱（±）-crispine A化学酶法去消旋化中的应用。
A template-based mnemonic for monoamine oxidase (MAO-N) catalyzed reactions and its application to the chemo-enzymatic deracemisation of the alkaloid (+/-)-crispine A.
作者信息
Bailey Kevin R, Ellis Andrew J, Reiss Renate, Snape Timothy J, Turner Nicholas J
机构信息
School of Chemistry, University of Manchester, Manchester Interdisciplinary Biocentre, 131 Princess Street, Manchester, UKM1 7DN.
出版信息
Chem Commun (Camb). 2007 Sep 21(35):3640-2. doi: 10.1039/b710456a. Epub 2007 Aug 8.
DOI:10.1039/b710456a
PMID:17728879
Abstract
A template-based mnemonic has been developed for the enzyme monoamine oxidase from Aspergillus niger and has been used to successfully identify the alkaloid (+/-)-crispine A as a target for chemo-enzymatic deracemisation yielding the biologically active (R)-enantiomer in 97% e.e.
摘要
已针对黑曲霉的单胺氧化酶开发了一种基于模板的记忆法，并已成功用于鉴定生物碱（±）-克里斯平A作为化学酶法去消旋化的目标，该方法可产生对映体过量值为97%的生物活性（R）-对映体。
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