通过串联生物催化/Ugi/Pictet-Spengler 型环化序列进行合成生物碱的不对称合成。
Asymmetric synthesis of synthetic alkaloids by a tandem biocatalysis/Ugi/Pictet-Spengler-type cyclization sequence.
机构信息
Department of Chemistry & Pharmaceutical Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.
出版信息
Chem Commun (Camb). 2010 Nov 7;46(41):7706-8. doi: 10.1039/c0cc02938f. Epub 2010 Sep 27.
PMID:20871902
Abstract
We have combined the biocatalytic desymmetrization of 3,4-cis-substituted meso-pyrrolidines with an Ugi-type multicomponent reaction followed in situ by a Pictet-Spengler-type cyclization reaction sequence for the rapid asymmetric synthesis of alkaloid-like polycyclic compounds.
摘要
我们将 3,4-顺式取代的内消旋吡咯烷的生物催化去对称化与 Ugi 型多组分反应相结合，随后进行原位 Pictet-Spengler 型环化反应序列，从而快速不对称合成类似生物碱的多环化合物。
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