维生素D缺乏时3',5'-环磷酸腺苷的尿排泄情况
Urinary excretion of adenosine 3'5' monophosphate in vitamin D deficiency.
作者信息
Vainsel M, Manderlier T, Otten J
出版信息
Eur J Clin Invest. 1976 Mar 31;6(2):127-30. doi: 10.1111/j.1365-2362.1976.tb00502.x.
Urinary cyclic adenosine 3'5' monophosphate (AMP) excretion has been determined by radioimmunoassay in children with rickets and in control children. Cyclic AMP was greatly increased in children with rickets. The excretion of cyclic AMP correlated significantly with parathyroid hormone levels (PTH) and alkaline phosphatase, but not with age, calcaemia and serum inorganic phosphate. Calcium infusion led to a decrease in the excretion of cyclic AMP. The data are consistent with following hypothesis. During vitamin D deficiency, high PTH levels can increase the renal excretion of cyclic AMP. The effects of PTH on bone resorption fail to maintain the levels of serum calcium due to the lack of vitamin D. The mechanism by which the secondary hyperparathyroidism develops during vitamin D deficiency remains to be investigated.
已通过放射免疫分析法测定了佝偻病患儿和对照儿童的尿中环磷酸腺苷（cAMP）排泄量。佝偻病患儿的环磷酸腺苷排泄量大幅增加。环磷酸腺苷的排泄量与甲状旁腺激素水平（PTH）和碱性磷酸酶显著相关，但与年龄、血钙和血清无机磷无关。钙输注导致环磷酸腺苷排泄量减少。这些数据与以下假设一致。在维生素D缺乏期间，高甲状旁腺激素水平可增加肾脏中环磷酸腺苷的排泄。由于缺乏维生素D，甲状旁腺激素对骨吸收的作用无法维持血钙水平。维生素D缺乏期间继发性甲状旁腺功能亢进的发生机制仍有待研究。
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