Mallet E, Bousnina S, Tron P, Basuyau J P, Brunelle P, de Menibus C H
Arch Fr Pediatr. 1977 Aug-Sep;34(7):632-8.
The study concerned 16 cases of deficiency rickets observed over 3 years. The level of serum parathyroid (IPTH) hormone was always increased in the late stages of rickets, but was normal in 3 cases of early rickets with hypocalcaemia and monophosphataemia. There was no statistical correlation between the level of IPTH and monophosphataemia. There was no statistical correlation between the level of IPTH and calcaemia. After vitamin D-therapy, the levels if IPTH returned to normal in 5 to 21 days in most cases. No obvious difference was noted in this evolution between children treated by vitamin D2 and 25 OH D. The excretion of urinary cyclic adenosine monophosphate decreases in parallel with blood IPTH.
该研究涉及3年内观察到的16例维生素D缺乏性佝偻病病例。佝偻病晚期血清甲状旁腺激素(IPTH)水平总是升高,但3例伴有低钙血症和低磷血症的早期佝偻病患者该水平正常。IPTH水平与低磷血症之间无统计学相关性。IPTH水平与血钙水平之间无统计学相关性。维生素D治疗后,大多数病例中IPTH水平在5至21天恢复正常。维生素D2和25-OH D治疗的儿童在这一变化过程中未观察到明显差异。尿中环磷酸腺苷的排泄与血液中IPTH水平平行下降。