维生素D缺乏性佝偻病患者的甲状旁腺激素和降钙素水平

Parathyroid hormone and calcitonin levels in vitamin D deficient rickets.

作者信息

Zamboni G, Cecchettin M, Albertini A, Andreoli A, Zoppi G

出版信息

Eur J Pediatr. 1979 Feb 8;130(2):137-45. doi: 10.1007/BF00442350.

Abstract

In six infants aged between 5 and 8 months with vitamin D deficient rickets, we have studied blood levels of calcium (Ca), phosphorus (P), alkaline phosphatase, immunoreactive parathyroid hormone (PTH) and calcitonin (CT), as well as urinary excretion of Ca, P, hydroxyproline and cyclic AMP, both under basal conditions and during a 4h infusion of 20 mg/kg 10% Ca gluconate in normal saline. Under basal conditions all the infants had high alkaline phosphatase (range: 470--770 U.I./1); PTH (range: 620--1200 pg Eq/ml) and CT (range: 440--750 pg/ml) but two infants had hypocalcaemia and four had normocalcaemia and hypophosphataemia. The urinary Ca excretion was low whereas the urinary P, hydroxyproline and cyclic AMP excretions were high. During Ca infusion the total serum Ca and CT levels increased, while alkaline phosphatase and PTH fell. After the end of the infusion, CT levels fell perceptibly; phosphaturia, hydroxyprolinuria and cyclic AMP decreased on the day of the infusion.

摘要

在6例年龄在5至8个月的维生素D缺乏性佝偻病婴儿中，我们研究了基础状态下以及在4小时内静脉输注20mg/kg 10%葡萄糖酸钙生理盐水期间，婴儿血液中的钙（Ca）、磷（P）、碱性磷酸酶、免疫反应性甲状旁腺激素（PTH）和降钙素（CT）水平，以及尿中Ca、P、羟脯氨酸和环磷酸腺苷（cAMP）的排泄情况。基础状态下，所有婴儿碱性磷酸酶水平均较高（范围：470 - 770 U.I./1）；PTH（范围：620 - 1200 pg Eq/ml）和CT（范围：440 - 750 pg/ml），但有2例婴儿存在低钙血症，4例婴儿血钙正常但有低磷血症。尿Ca排泄量低，而尿P、羟脯氨酸和cAMP排泄量高。在输注钙期间，血清总Ca和CT水平升高，而碱性磷酸酶和PTH水平下降。输注结束后，CT水平明显下降；输注当天磷尿、羟脯氨酸尿和cAMP排泄量减少。