Welsh Robert C, Rahbar Habib, Foerster Bradley, Thurnher Majda, Sundgren Pia C
Department of Radiology, Basic Radiological Sciences Division, University Hospital of Michigan, Ann Arbor, Michigan 48109-0553, USA.
J Magn Reson Imaging. 2007 Sep;26(3):541-51. doi: 10.1002/jmri.21036.
To investigate the source of significant difference in apparent diffusion coefficient (ADC) between patients with acute symptoms of neuropsychiatric (NP) systematic lupus erythematosus (SLE) (NPSLE) and normal controls.
Diffusion-weighted echo-planar imaging was performed on 1.5-T scanners in 17 female and four male NPSLE patients with acute neurological symptoms (23-76 years, mean = 42.7 years), and in 21 aged-matched healthy controls (16 female, five male, 26-63 years, mean = 41.1 years). ADC histograms were calculated for whole brain, gray matter tissue, and white matter tissue.
Of the 17 NPSLE patients, 13 (72%) had abnormal findings on MR imaging. The NPSLE patients had a mean ADC value of (1105.1 +/- 23.6) x 10(-6) mm(2)/second and the control had a mean ADC value of (1012.5 +/- 9.4) x 10(-6) mm(2)/second (P < or = 0.0012). Significant differences were also found in white matter (P < or = 0.0020) and gray matter (P < or = 0.0022).
ADC histogram analysis demonstrated increased general diffusivity in the brain in NPSLE patients with acute symptoms compared with healthy normal controls. This finding suggests that in the brain parenchyma of NPSLE patients a loss of tissue integrity occurs facilitating motility of free-water protons.
探讨患有神经精神性（NP）系统性红斑狼疮（SLE）（NPSLE）急性症状的患者与正常对照者之间表观扩散系数（ADC）存在显著差异的来源。
在1.5-T扫描仪上对17例有急性神经症状的女性和4例男性NPSLE患者（年龄23 - 76岁，平均42.7岁）以及21例年龄匹配的健康对照者（16例女性，5例男性，年龄26 - 63岁，平均41.1岁）进行扩散加权回波平面成像。计算全脑、灰质组织和白质组织的ADC直方图。
17例NPSLE患者中，13例（72%）磁共振成像有异常表现。NPSLE患者的平均ADC值为（1105.1±23.6）×10⁻⁶mm²/秒，对照组的平均ADC值为（1012.5±9.4）×10⁻⁶mm²/秒（P≤0.0012）。在白质（P≤0.0020）和灰质（P≤0.0022）中也发现了显著差异。
ADC直方图分析表明，与健康正常对照者相比，有急性症状的NPSLE患者脑内的总体扩散率增加。这一发现表明，在NPSLE患者的脑实质中发生了组织完整性丧失，从而促进了自由水质子的运动。
