Mortimer P S, Simmonds R H, Rezvani M, Robbins M E, Ryan T J, Hopewell J W
Department of Dermatology, Slade Hospital, Oxford, UK.
Br J Radiol. 1991 Dec;64(768):1140-6. doi: 10.1259/0007-1285-64-768-1140.
The early and late effects of X rays on lymphatic microcirculatory function have been investigated in pig skin. Paired estimates of lymph clearance were performed in irradiated and unirradiated sites on the flank skin of anaesthetized Large White pigs at 3, 6, 9, 12, 26, 39, 52, 64 and 78 weeks after a single dose of 18 Gy of X rays. The dermal clearance of 99Tcm-colloid was used to assess lymph flow. The results demonstrated two waves of impaired lymphatic clearance which correlated well with the gross morphological changes observed. The first wave occurred between 6 and 12 weeks after irradiation and corresponded to a period of ischaemia and oedema. The second wave, at 52 weeks, corresponded with dermal thinning and subcutaneous atrophy. X irradiation resulted in an impairment of lymph drainage both within and outside the field of irradiation. Impaired lymphatic drainage probably contributes to the gross and histological changes observed in the skin after X irradiation.
在猪皮肤中研究了X射线对淋巴微循环功能的早期和晚期影响。在给麻醉的大白猪单次给予18 Gy X射线后的3、6、9、12、26、39、52、64和78周，对其侧腹皮肤的照射部位和未照射部位进行淋巴清除率的配对估计。用99锝胶体的皮肤清除率评估淋巴流量。结果显示淋巴清除受损有两个阶段，这与观察到的大体形态学变化密切相关。第一阶段发生在照射后6至12周，对应于缺血和水肿期。第二阶段在52周时，与皮肤变薄和皮下萎缩相对应。X射线照射导致照射野内外的淋巴引流受损。淋巴引流受损可能是X射线照射后皮肤出现大体和组织学变化的原因。
