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自闭症:其主要的心理和神经缺陷。

Autism: its primary psychological and neurological deficit.

作者信息

Fotheringham J B

机构信息

Department of Psychiatry, Queen's University, Kingston, Ontario.

出版信息

Can J Psychiatry. 1991 Nov;36(9):686-92. doi: 10.1177/070674379103600913.

DOI:10.1177/070674379103600913
PMID:1773407
Abstract

Autism is a perplexing condition because of its unique presenting signs and high degree of variability. Evidence is presented that the basic underlying information processing disorder is a dysfunction of the appreciation of the emotional significance of incoming stimuli and attaching motivational value to the stimuli. It is proposed that this dysfunction occurs when the amygdaloid nucleus and/or its connections are disrupted, resulting in the variability of the presentation of this syndrome among individuals. Herpes simplex encephalitis sometimes results in signs of autism. The virus has a predilection to attack specific areas of the brain, which provides information on the probable underlying neurological dysfunction in autism.

摘要

自闭症是一种令人困惑的病症,因其独特的表现症状和高度的变异性。有证据表明,基本的潜在信息处理障碍是对传入刺激的情感意义缺乏认知以及无法赋予刺激动机价值的功能障碍。有人提出,当杏仁核及其连接受到破坏时,就会出现这种功能障碍,从而导致该综合征在个体间表现出变异性。单纯疱疹性脑炎有时会导致自闭症症状。该病毒倾向于攻击大脑的特定区域,这为自闭症可能的潜在神经功能障碍提供了信息。

相似文献

1
Autism: its primary psychological and neurological deficit.自闭症:其主要的心理和神经缺陷。
Can J Psychiatry. 1991 Nov;36(9):686-92. doi: 10.1177/070674379103600913.
2
Autism.自闭症
New Dir Ment Health Serv. 1992 Summer(54):19-23. doi: 10.1002/yd.23319925405.
3
Brief report: autism and herpes simplex encephalitis.简短报告:自闭症与单纯疱疹性脑炎
J Autism Dev Disord. 1992 Mar;22(1):107-13. doi: 10.1007/BF01046406.
4
Quantified multidimensional assessment of autism and other pervasive developmental disorders. Application for bioclinical research.自闭症及其他广泛性发育障碍的量化多维评估。生物临床研究应用。
Eur Child Adolesc Psychiatry. 1995 Apr;4(2):123-35. doi: 10.1007/BF01977740.
5
Brief report: neuropsychological testing of autistic children through an exploration with frontal lobe tests.简短报告:通过额叶测试探索对自闭症儿童进行神经心理学测试。
J Autism Dev Disord. 1990 Dec;20(4):581-90. doi: 10.1007/BF02216063.
6
Autism and known medical conditions: myth and substance.自闭症与已知的医学状况:误区与实质
J Child Psychol Psychiatry. 1994 Feb;35(2):311-22. doi: 10.1111/j.1469-7610.1994.tb01164.x.
7
Annotation: current psychological theories of autism: the "theory of mind" account and rival theories.注释:当前关于自闭症的心理学理论:“心理理论”解释及其他相关理论。
J Child Psychol Psychiatry. 1994 Feb;35(2):215-29. doi: 10.1111/j.1469-7610.1994.tb01159.x.
8
Brief report: developmental neurobiological aspects of autism.简短报告:自闭症的发育神经生物学方面
J Autism Dev Disord. 1996 Apr;26(2):189-93. doi: 10.1007/BF02172010.
9
Brief report: parental age in infantile autism, autistic-like conditions, and borderline childhood psychosis.简短报告:婴儿自闭症、类自闭症状况及边缘性儿童期精神病中的父母年龄
J Autism Dev Disord. 1993 Jun;23(2):387-96. doi: 10.1007/BF01046227.
10
Infantile autism and the temporal lobe of the brain.小儿自闭症与大脑颞叶
J Autism Dev Disord. 1981 Sep;11(3):317-30. doi: 10.1007/BF01531514.

引用本文的文献

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The Role of the Noradrenergic System in Autism Spectrum Disorders, Implications for Treatment.去甲肾上腺素系统在自闭症谱系障碍中的作用及其治疗意义。
Semin Pediatr Neurol. 2020 Oct;35:100834. doi: 10.1016/j.spen.2020.100834. Epub 2020 Jun 24.
2
Research review: Constraining heterogeneity: the social brain and its development in autism spectrum disorder.研究综述:约束异质性:自闭症谱系障碍中的社会大脑及其发育。
J Child Psychol Psychiatry. 2011 Jun;52(6):631-44. doi: 10.1111/j.1469-7610.2010.02349.x. Epub 2011 Jan 19.
3
Effect of propranolol on functional connectivity in autism spectrum disorder--a pilot study.
普萘洛尔对自闭症谱系障碍功能连接的影响——一项初步研究。
Brain Imaging Behav. 2010 Jun;4(2):189-97. doi: 10.1007/s11682-010-9098-8.
4
Affective modulation of the startle eyeblink and postauricular reflexes in autism spectrum disorder.自闭症谱系障碍中惊跳眨眼和耳后反射的情感调制。
J Autism Dev Disord. 2010 Jul;40(7):858-69. doi: 10.1007/s10803-009-0925-y.
5
Autistic disorder and viral infections.自闭症谱系障碍与病毒感染。
J Neurovirol. 2005 Feb;11(1):1-10. doi: 10.1080/13550280590900553.
6
The effect of semantic and emotional context on written recall for verbal language in high functioning adults with autism spectrum disorder.语义和情感背景对高功能自闭症谱系障碍成年人言语语言书面回忆的影响。
J Neurol Neurosurg Psychiatry. 1998 Nov;65(5):685-92. doi: 10.1136/jnnp.65.5.685.