Integrated Biomedical Sciences Graduate Program, The Ohio State University, Columbus, OH, USA.
Brain Imaging Behav. 2010 Jun;4(2):189-97. doi: 10.1007/s11682-010-9098-8.
A decrease in interaction between brain regions is observed in individuals with autism spectrum disorder (ASD), which is believed to be related to restricted neural network access in ASD. Propranolol, a beta-adrenergic antagonist, has revealed benefit during performance of tasks involving flexibility of access to networks, a benefit also seen in ASD. Our goal was to determine the effect of propranolol on functional connectivity in ASD during a verbal decision making task as compared to nadolol, thereby accounting for the potential spurious fMRI effects due to peripheral hemodynamic effects of propranolol. Ten ASD subjects underwent fMRI scans after administration of placebo, propranolol or nadolol, while performing a phonological decision making task. Comparison of functional connectivity between pre-defined ROI-pairs revealed a significant increase with propranolol compared to nadolol, suggesting a potential imaging marker for the cognitive effects of propranolol in ASD.
在自闭症谱系障碍（ASD）患者中观察到大脑区域之间的相互作用减少，这被认为与 ASD 中受限的神经网络访问有关。普萘洛尔是一种β肾上腺素能拮抗剂，在涉及网络访问灵活性的任务中表现出益处，在 ASD 中也观察到了这种益处。我们的目标是确定与那洛尔相比，普萘洛尔对 ASD 患者在言语决策任务中功能连接的影响，从而解释由于普萘洛尔的外周血液动力学效应而导致的潜在虚假 fMRI 效应。10 名 ASD 受试者在服用安慰剂、普萘洛尔或那洛尔后进行 fMRI 扫描，同时执行语音决策任务。与预定义 ROI 对之间的功能连接比较显示，与那洛尔相比，普萘洛尔有显著增加，这表明普萘洛尔在 ASD 中的认知效应的潜在成像标志物。
