Ardaillou R, Isaac R, Nivez M P, Kuhn J M, Cazor J L, Fillastre J P
Horm Metab Res. 1976 Mar;8(2):136-40. doi: 10.1055/s-0028-1093669.
Intravenous infusion of salmon calcitonin in six healthy subjects produced an increase in the plasma levels and urinary excretion of cyclic AMP. Cyclic AMP clearance diminished but remained higher than inulin clearance. Salmon calcitonin was also infused in six hypertensive patients with normal glomerular filtration rate. Arterial and renal venous plasma concentration of cyclic AMP were clearly raised. The difference between both these concentrations was not significant in the control periods but became marked during the treatment and post treatment periods demonstrating a net extraction of cyclic AMP from plasma by the kidneys. Renal extraction of cyclic AMP was lower than its urinary excretion in the control periods whereas it was clearly higher after salmon calcitonin was given. This shows that salmon calcitonin stimulates the production of cyclic AMP in extra-renal tissues and that the excess of cyclic AMP formed is catabolized by the kidneys.
对6名健康受试者静脉输注鲑鱼降钙素后，血浆中环磷酸腺苷（cAMP）水平及尿中cAMP排泄量增加。cAMP清除率降低，但仍高于菊粉清除率。对6名肾小球滤过率正常的高血压患者也输注了鲑鱼降钙素。动脉血和肾静脉血浆中的cAMP浓度明显升高。在对照期，这两种浓度之间的差异不显著，但在治疗期和治疗后期变得明显，表明肾脏从血浆中净提取了cAMP。在对照期，肾脏对cAMP的提取低于其尿排泄量，而在给予鲑鱼降钙素后则明显更高。这表明鲑鱼降钙素刺激肾外组织中cAMP的产生，并且所形成的过量cAMP被肾脏分解代谢。
