Kuhn J M, Cazor J L, Isaac R, Nivez M P, Ardaillou R, Fillastre J P
C R Seances Soc Biol Fil. 1976;170(2):449-55.
Intravenous infusion of salmon calcitonin in man produced an increase in the plasma levels and urinary excretion of cyclic AMP. This study demonstrates a net extraction of cyclic AMP from plasma by the kidneys but salmon calcitonin does not act only on the kidney and stimulates the production of cyclic AMP in extra renal tissues. The excess of cyclic AMP formed is catabolized by the kidneys.
给人体静脉输注鲑鱼降钙素会使血浆中环磷酸腺苷(cAMP)水平升高及尿中cAMP排泄增加。本研究表明肾脏可从血浆中净提取cAMP,但鲑鱼降钙素并非仅作用于肾脏,还能刺激肾外组织产生cAMP。所形成的过量cAMP会被肾脏分解代谢。