Terenzi H F, Flawia M M, Tellez-Inon M T, Torres H N
J Bacteriol. 1976 Apr;126(1):91-9. doi: 10.1128/jb.126.1.91-99.1976.
The role of cyclic adenosine 3', 5'-monophosphate (cyclic AMP) in the control of the Neurospora asexual life cycle was studied. Endogenous cyclic AMP levels were 10 to 20 times higher in strains having the wild-type cr-1 allele than in those carrying the mutated allele. In a wild-type strain these levels remained constant throughtout the entire growth period in shaken liquid cultures, except during a short period at the beginning of the stationary growth phase. In this period a marked increase in the cyclic nucleotide level was observed. The culture of cr-1 mutant strains in the presence of cyclic AMP or its dibutyryl derivative restores some morphological properties characteristic of wild-type strains. Specifically these cyclic nucleotides stimulated the rate of mycelial elongation, as well as the differentiation of aerial hyphae.
研究了3',5'-环磷酸腺苷（环磷腺苷）在控制粗糙脉孢菌无性生命周期中的作用。具有野生型cr-1等位基因的菌株内源性环磷腺苷水平比携带突变等位基因的菌株高10至20倍。在野生型菌株中，在振荡液体培养的整个生长期间，这些水平保持恒定，除了在稳定生长期开始时的短时间内。在此期间，观察到环核苷酸水平显著增加。在环磷腺苷或其二丁酰衍生物存在下培养cr-1突变菌株可恢复野生型菌株的一些形态学特性。具体而言，这些环核苷酸刺激了菌丝伸长率以及气生菌丝的分化。
