Johnson T L, Sakaguchi A Y, Lalley P A, Leach R J
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284.
Genomics. 1991 Nov;11(3):770-2. doi: 10.1016/0888-7543(91)90089-w.
Matrix Gla protein (MGLAP) and bone Gla protein (BGLAP) are calcium-binding, vitamin K-dependent proteins produced by cells of the osteoblastic lineage. Sequence homology suggests that the genes for these proteins evolved from a common ancestor. Somatic whole cell hybrids and karyotypically simple microcell hybrids were used to map Mglap to mouse Chromosome 6 and Bglap to mouse Chromosome 3. Human MGLAP has previously been mapped to chromosome 12p, a region with homology to mouse Chromosome 6, and human BGLAP has been mapped to chromosome 1q, a region with homology to mouse Chromosome 3. It appears that BGLAP is the third calcium-binding protein that maps to human chromosome 1q and mouse Chromosome 3.
基质γ-羧基谷氨酸蛋白（MGLAP）和骨γ-羧基谷氨酸蛋白（BGLAP）是由成骨细胞谱系细胞产生的钙结合、维生素K依赖蛋白。序列同源性表明这些蛋白的基因起源于一个共同的祖先。利用体细胞全细胞杂种和核型简单的微细胞杂种将Mglap定位到小鼠6号染色体，将Bglap定位到小鼠3号染色体。人类MGLAP先前已被定位到12号染色体短臂，该区域与小鼠6号染色体同源，而人类BGLAP已被定位到1号染色体长臂，该区域与小鼠3号染色体同源。看来BGLAP是定位到人类1号染色体长臂和小鼠3号染色体的第三种钙结合蛋白。
