Grimes R, Reddy S V, Leach R J, Scarcez T, Roodman G D, Sakaguchi A Y, Lalley P A, Windle J J
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284.
Genomics. 1993 Feb;15(2):421-2. doi: 10.1006/geno.1993.1079.
Tartrate-resistant acid phosphatase is a marker enzyme for osteoclasts, the multinucleated cell responsible for bone resorption. Interspecific somatic whole cell hybrids and karyotypically simple microcell hybrids were used to map the gene encoding tartrate-resistant acid phosphatase (Acp5) to mouse Chromosome 9. Acp5 is therefore a member of a syntenic family of genes that map to human chromosome 19p13.1-p13.3 and mouse Chromosome 9.
抗酒石酸酸性磷酸酶是破骨细胞的一种标志酶,破骨细胞是负责骨吸收的多核细胞。种间体细胞全细胞杂种和核型简单的微细胞杂种被用于将编码抗酒石酸酸性磷酸酶(Acp5)的基因定位到小鼠9号染色体上。因此,Acp5是一个同线基因家族的成员,这些基因定位到人类染色体19p13.1 - p13.3和小鼠9号染色体上。