Pant K K, Tangri K K, Bhargava K P
Department of Pharmacology & Therapeutics, King George's Medical College, Lucknow.
Indian J Med Res. 1991 Dec;94:447-51.
The present study demonstrates the effect of activation of spinal serotonergic receptors on heart rate, blood pressure and cardiac arrhythmia induced by coronary artery ligation in cervical spinal cord transected and bilaterally vagotomized dogs. Intrathecal injection of serotonin (5-HT) evoked a fall in blood pressure (mean decrease, 16 +/- 3) and a decrease in heart rate (mean change, 24 +/- 6) and these effects were blocked by intrathecal pretreatment with methysergide. The magnitude of ventricular ectopics evoked by coronary artery ligation was decreased by serotonin (mean decrease, 31 +/- 5%), and this effect of serotonin was blocked by methysergide pretreatment intrathecally (mean change, 7 +/- 5%). Methysergide per se, increased the magnitude of ventricular ectopics (mean increase, 24 +/- 5%). The serotonergic receptors of the spinal cord appear to have an inhibitory influence on the cardiovascular functions.
本研究证实了脊髓5-羟色胺能受体激活对颈髓横断并双侧迷走神经切断犬冠状动脉结扎所致心率、血压及心律失常的影响。鞘内注射5-羟色胺（5-HT）可引起血压下降（平均下降16±3）和心率降低（平均变化24±6），这些效应可被鞘内预先给予麦角新碱阻断。冠状动脉结扎诱发的室性早搏数量可被5-羟色胺减少（平均减少31±5%），5-羟色胺的这一效应可被鞘内预先给予麦角新碱阻断（平均变化7±5%）。麦角新碱本身可增加室性早搏数量（平均增加24±5%）。脊髓的5-羟色胺能受体似乎对心血管功能具有抑制作用。
