Ramirez A J, Giarcovich S S, Enero M A
J Hypertens Suppl. 1986 Apr;4(1):S47-9.
The present study concerns the involvement of descending bulbospinal serotonergic pathways in blood pressure regulation in both normotensive and neurogenically hypertensive rats. We found that direct stimulation of serotonergic receptors of the spinal cord induced a depressor response which was prevented by prior catecholaminergic denervation in anaesthetized normotensive rats. Twenty-four hours after neurogenic hypertension, depletion of the serotonergic system provoked a further increase in blood pressure in conscious rats. We suggest that stimulation of pre-synaptic serotonergic receptors localized on spinal catecholaminergic neurons decreases blood pressure. This hypotensive mechanism could be activated after baroreflex deafferentation to prevent a further increase in blood pressure.
本研究关注下行延髓脊髓5-羟色胺能通路在正常血压大鼠和神经源性高血压大鼠血压调节中的作用。我们发现，直接刺激脊髓5-羟色胺能受体可诱发降压反应，在麻醉的正常血压大鼠中，这种反应可被预先的儿茶酚胺能去神经支配所阻断。神经源性高血压24小时后，5-羟色胺能系统的耗竭会使清醒大鼠的血压进一步升高。我们认为，刺激位于脊髓儿茶酚胺能神经元上的突触前5-羟色胺能受体可降低血压。这种降压机制可在压力反射传入神经切断后被激活，以防止血压进一步升高。
