Derijk R, Berkenbosch F
Department of Pharmacology, Medical Faculty, Free University, Amsterdam, The Netherlands.
Int J Neurosci. 1991 Jul;59(1-3):91-100. doi: 10.3109/00207459108985452.
Immunoendocrinology is a rapidly expanding field, uncovering numerous bilateral interactions between the immune system and neuroendocrine circuits. Various hormones and neurotransmitters appear to modulate cells of the immune system and likewise cytokines control the function of neuroendocrine system. In the present paper, we discuss some lines of evidence indicating that an immunoendocrine feedback loop, which we term 'immune-hypothalamo-pituitary-adrenal system' is an integral part of the regulation of self tolerance. The finding that pathology of this immunoendocrine feedback loop is related to development of autoimmunity may lead to new prophylactic and therapeutic strategies.
免疫内分泌学是一个迅速发展的领域，揭示了免疫系统与神经内分泌回路之间众多的双向相互作用。各种激素和神经递质似乎调节免疫系统的细胞，同样，细胞因子也控制神经内分泌系统的功能。在本文中，我们讨论了一些证据表明，我们称之为“免疫-下丘脑-垂体-肾上腺系统”的免疫内分泌反馈回路是自我耐受调节的一个组成部分。这一免疫内分泌反馈回路的病理学与自身免疫性疾病的发生有关这一发现，可能会带来新的预防和治疗策略。
