Brown D T, Miller C H, Maupin D E
Department of Prosthodontics, Indiana University, School of Dentistry, Indianapolis.
J Prosthet Dent. 1991 Aug;66(2):256-60. doi: 10.1016/s0022-3913(05)80057-5.
Sucralfate, an aluminum salt of sucrose octasulfate, has been shown to be effective in reducing the discomfort of radiation therapy-induced oral mucositis. This study was done to determine whether sucralfate could be used as a nutritional source for dental caries-producing organisms. Three Streptococcus strains were cultured in a defined medium. Sucralfate powder was evaluated for its ability to be used as a carbohydrate food source by these organisms. The addition of sucralfate alone did not stimulate the organism's growth. The addition of sucralfate and glucose resulted in less growth than the addition of glucose alone. Increasing the sucralfate concentration from 1% to 10% in the glucose-containing cultures resulted in statistically significant growth inhibition (p less than 0.02). Sucralfate appears to have no cariogenic potential and may have some cariostatic potential.
硫糖铝，一种蔗糖八硫酸酯的铝盐，已被证明在减轻放射治疗引起的口腔粘膜炎的不适方面有效。本研究旨在确定硫糖铝是否可作为致龋生物体的营养来源。在特定培养基中培养了三种链球菌菌株。评估了硫糖铝粉末作为这些生物体碳水化合物食物来源的能力。单独添加硫糖铝不会刺激生物体生长。添加硫糖铝和葡萄糖导致的生长比单独添加葡萄糖少。在含葡萄糖的培养物中将硫糖铝浓度从1%提高到10%导致具有统计学意义的生长抑制（p小于0.02）。硫糖铝似乎没有致龋潜力，可能具有一定的抑龋潜力。
