Ji Z L, Chen H R, Lei R Q, Yang J Z, Huang M H
Department of Surgery, Nanjing Railway Medical College, Jiangsu, China.
J R Coll Surg Edinb. 1991 Dec;36(6):395-8.
In this preliminary study a flexible bipolar microwave electrode, 1.8 mm in diameter, was designed to occlude the cystic duct in 18 rabbits. Thermal model tests were performed to evaluate the effect of the antenna and to master the coagulating condition. Through surgical cholecystostomy, the antenna was inserted into the proximal cystic duct for various coagulation treatments. Cholecystography showed that the cystic duct was occluded minutes to hours after coagulation. Histologically, the microwave technique induced a chronic inflammation and fibrosis which eventually obliterated the coagulated cystic duct permanently. In group A (30 mA for 20 s) the cystic duct epithelium regeneration occurred and surrounding liver damage was limited, while in groups B (50 mA for 10 s) and C (70 mA for 6 s) no epithelium regeneration was observed and injury to the liver was mild to moderate. It was found that microwaves generated at 50 mA for 10 s to occlude the rabbit's cystic duct are effective and less injurious.
在这项初步研究中，设计了一种直径为1.8毫米的柔性双极微波电极，用于阻塞18只兔子的胆囊管。进行了热模型测试，以评估天线的效果并掌握凝固条件。通过外科胆囊造口术，将天线插入胆囊管近端进行各种凝固治疗。胆囊造影显示，凝固后数分钟至数小时胆囊管被阻塞。组织学检查表明，微波技术引发了慢性炎症和纤维化，最终永久性地闭塞了凝固的胆囊管。在A组（30毫安，持续20秒）中，胆囊管上皮发生再生，周围肝脏损伤有限，而在B组（50毫安，持续10秒）和C组（70毫安，持续6秒）中，未观察到上皮再生，肝脏损伤为轻度至中度。结果发现，以50毫安持续10秒产生的微波阻塞兔子的胆囊管是有效的，且损伤较小。
