Dong B, Liang P, Yu X
Department of Ultrasound, Chinese PLA General Hospital, Beijing.
Zhonghua Yi Xue Za Zhi. 1996 Feb;76(2):87-91.
To completely coagulate deep tumor and protect normal tissue by using microwave electrode is vivo and in vitro animal experimental study, under US-guided percutaneous microwave coagulation.
The Ultrasound Microwave Therapy-I (UMT-I) equipment was utilized at 2450 MHz in frequency.
Microwave coagulation could produce a stable necrosis area of 2cm in diameter with irradiation at 60-80W for 60-180 seconds, and the corresponding temperature at its surrounding area was 61.95 +/- 5.81 degrees C. Microwave induced coagulation of tumor correlated well with the sonographic changes. The shape of coagulated area was elliptic when 27 mm or 9 mm of the inner conductor of electrode was exposed, and the temperature of the shaft of the electrode raised smaller and slowly based on our animal experimental study, 15 nodules of 12 patients with liver cancer were microwave-coagulated under US-guide. The temperature of tumor surrounding area raised to 54-69.5 degrees C during operation. After treatment, all lesions had smaller size, hypoechogenicity and disappearance of blood flow. AFP titer dropped in 7 patients and normalized in 4.
US-guided microwave for the treatment of liver cancer is effective in coagulating deep tumor and protecting normal tissue.
通过超声引导下经皮微波凝固，在体内外动物实验研究中使用微波电极完全凝固深部肿瘤并保护正常组织。
使用频率为2450MHz的超声微波治疗仪-I（UMT-I）设备。
在60 - 80W照射60 - 180秒时，微波凝固可产生直径2cm的稳定坏死区，其周边相应温度为61.95±5.81℃。微波诱导的肿瘤凝固与超声变化密切相关。根据动物实验研究，当电极内导体露出27mm或9mm时，凝固区形状为椭圆形，电极杆部温度升高较小且缓慢。12例肝癌患者的15个结节在超声引导下进行了微波凝固。术中肿瘤周边温度升至54 - 69.5℃。治疗后，所有病灶体积缩小、回声减低且血流信号消失。7例患者甲胎蛋白（AFP）滴度下降，4例恢复正常。
超声引导下微波治疗肝癌在凝固深部肿瘤及保护正常组织方面是有效的。
