Chugh Y, Saha N, Sankaranarayanan A, Datta H
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Pharmacol Toxicol. 1991 Aug;69(2):105-6. doi: 10.1111/j.1600-0773.1991.tb01280.x.
Experimental evidence suggests an important role of serotonin in the process of learning and memory. The present study investigated the effect of 5HT3-receptor antagonist (ICS 205-930) on retrieval of a previously learned aversive habit in the mouse. The effect of ICS 205-930 on scopolamine (3 mg/kg) induced amnesia was also studied. ICS 205-930 (1, 10 & 100 micrograms/kg) produced a dose-dependent increase in latency to cross into the dark chamber. The scopolamine induced memory impairment was significantly attenuated by ICS 205-930 (10 micrograms/kg). These results suggest that memory deficits may be susceptible to attenuation with non-cholinergic treatments.
实验证据表明血清素在学习和记忆过程中起重要作用。本研究调查了5-羟色胺3型受体拮抗剂（ICS 205-930）对小鼠先前习得的厌恶习性恢复的影响。还研究了ICS 205-930对东莨菪碱（3毫克/千克）诱导的失忆的影响。ICS 205-930（1、10和100微克/千克）使进入暗室的潜伏期呈剂量依赖性增加。ICS 205-930（10微克/千克）显著减轻了东莨菪碱诱导的记忆损伤。这些结果表明，记忆缺陷可能易于通过非胆碱能治疗得到缓解。
