Pitsikas N, Borsini F
Department of Biology, Boehringer Ingelheim Italia, Milano, Italy.
Pharmacol Biochem Behav. 1997 Apr;56(4):571-6. doi: 10.1016/s0091-3057(96)00516-3.
The effects of the 5-HT3 receptor antagonists tropisetron (ICS 205-930) and ondansetron on memory and performance impairments induced by scopolamine were tested in a passive avoidance procedure and in the Morris water maze task. Pretreatment with ondansetron (0.01 and 1 microgram/kg i.p.) but not with tropisetron (1, 10, and 30 micrograms/kg i.p.) reversed scopolamine-induced memory deficits in the step-through passive avoidance task. When the effects of these 5-HT3 receptor antagonists on cognition were assessed in the Morris water maze, ondansetron (0.01, 1, and 10 micrograms/kg i.p.) did not antagonize scopolamine-induced spatial navigation deficits. On the contrary, pretreatment with tropisetron (10 and 30 micrograms/kg, and to some extent also with 1 microgram/kg i.p.) counteracted the learning and memory impairment due to scopolamine treatment. The findings suggest that it could be worthwhile to investigate whether or not different subtypes of the 5-HT3 receptor may underlie the different effects on cognition displayed by compounds that belong to the same pharmacological class.
在被动回避程序和莫里斯水迷宫任务中，测试了5-羟色胺3（5-HT3）受体拮抗剂托烷司琼（ICS 205-930）和昂丹司琼对东莨菪碱诱导的记忆和行为损伤的影响。在穿梭式被动回避任务中，昂丹司琼（腹腔注射0.01和1微克/千克）预处理可逆转东莨菪碱诱导的记忆缺陷，但托烷司琼（腹腔注射1、10和30微克/千克）预处理则不能。当在莫里斯水迷宫中评估这些5-HT3受体拮抗剂对认知的影响时，昂丹司琼（腹腔注射0.01、1和10微克/千克）不能拮抗东莨菪碱诱导的空间导航缺陷。相反，托烷司琼（腹腔注射10和30微克/千克，在某种程度上1微克/千克也有此作用）预处理可抵消东莨菪碱处理所致的学习和记忆损伤。这些发现表明，研究5-HT3受体的不同亚型是否可能是同一药理类化合物对认知产生不同影响的基础，可能是有价值的。
