Science. 1946 Apr 12;103(2676):441-5. doi: 10.1126/science.103.2676.441.
The finding of abnormal estrogenic activity coupled with thiamine deficiency in cases of menorrhagia and uterine cancer suggests a possible etiological correlation between the dietary deficiency, the abnormal estrogen level, and the pathological lesion. The specific element deficient in these cases was thiamine, while the other B factors were normal. Preliminary report of the evidence is made in this small series while more extensive studies on a large series of cases are being pursued. Cornification in cytology smears was used to study estrogenic activity, since the present study was prompted by cytological findings; the method is simple, practical, and reasonably accurate. The urinary estimation measures only the amount excreted, and if liver impairment actually is present, the quantity excreted would not give a true index of the amount retained in the body. Further studies are being undertaken in which estrogenic, urinary, and cornification levels are being compared before and after thiamine administration in cases proven to be deficient.
月经过多和子宫癌病例中异常雌激素活性与硫胺素缺乏的发现表明，饮食缺乏、异常雌激素水平和病理损伤之间可能存在病因相关性。在这些病例中，缺乏的特定元素是硫胺素，而其他 B 族维生素是正常的。在这个小系列中初步报告了证据，同时正在对大量病例进行更广泛的研究。细胞学涂片中的角化被用来研究雌激素活性，因为本研究是根据细胞学发现而提出的；该方法简单、实用且相当准确。尿估计仅测量排泄量，如果确实存在肝损伤，则排泄量不会提供体内保留量的真实指标。正在进行进一步的研究，在已证明缺乏硫胺素的病例中，在给予硫胺素前后比较雌激素、尿和角化水平。
