Meert T F, Awouters F, Niemegeers C J, Schellekens K H, Janssen P A
Department of Neuropsychopharmacology, Janssen Research Foundation, Beerse, Belgium.
Pharmacopsychiatry. 1991 Sep;24(5):159-63. doi: 10.1055/s-2007-1014461.
Rats that had received 3% alcohol, 0.01% cocaine, or 0.002% fentanyl as the only beverage over 10 days showed marked preference for the drug solution when water was made available as a second fluid in a separate bottle. Treatment with low doses of ritanserin, a specific central serotonin 5-HT2 antagonist, rapidly reversed drug preference without changing total fluid intake. Quantitatively, the reduction in drug consumption was greater for alcohol than for cocaine and greater for cocaine than for fentanyl. This is probably related to differences in the reinforcing potential of the three drugs.
在10天时间里仅以3%酒精、0.01%可卡因或0.002%芬太尼作为唯一饮品的大鼠，当在另一个单独瓶子中提供水作为第二种液体时，对药物溶液表现出明显偏好。用低剂量的利坦色林（一种特异性中枢5-羟色胺5-HT2拮抗剂）进行治疗，能迅速逆转药物偏好，且不改变总液体摄入量。从数量上看，酒精的药物消耗量减少幅度大于可卡因，可卡因的减少幅度大于芬太尼。这可能与这三种药物强化潜力的差异有关。
