Ganesan R, Simpkins J W
Department of Pharmacodynamics, University of Florida, Gainesville 32610.
Physiol Behav. 1991 Oct;50(4):849-52. doi: 10.1016/0031-9384(91)90029-n.
In two experiments, ovariectomized rats were given a novel diet prior to the implantation of a fused pellet of estradiol (E2 pellet). In short-term (3 weeks) ovariectomized rats, the suppression of food intake induced by estrogen was not affected by the introduction of the novel diet. However, a sensitive two-choice preference test revealed that subjects implanted with the E2 pellet had a lesser preference for the novel diet than controls implanted with the vehicle pellet. In long-term (18 weeks) ovariectomized rats, implantation of the E2 pellet had a large effect on the consumption of the novel diet. Intake was reduced to less than 1 g in all subjects on Days 3-7 after E2 pellet implantation. A subsequent two-choice preference test indicated the presence of a strong aversion to the novel diet in the estradiol-treated rats relative to the controls. These experiments show that estradiol can induce conditioned taste aversions that have either no effect on intake or totally suppress food intake, depending upon postovariectomy time.
在两项实验中，对卵巢切除的大鼠在植入雌二醇融合丸剂（E2丸剂）之前给予新的饮食。在短期（3周）卵巢切除的大鼠中，雌激素诱导的食物摄入量抑制不受新饮食引入的影响。然而，一项敏感的双选偏好测试显示，植入E2丸剂的受试者对新饮食的偏好低于植入载体丸剂的对照组。在长期（18周）卵巢切除的大鼠中，植入E2丸剂对新饮食的消耗有很大影响。在植入E2丸剂后的第3 - 7天，所有受试者的摄入量降至1克以下。随后的双选偏好测试表明，与对照组相比，接受雌二醇治疗的大鼠对新饮食存在强烈的厌恶。这些实验表明，根据卵巢切除后的时间，雌二醇可以诱导条件性味觉厌恶，这种厌恶对摄入量要么没有影响，要么完全抑制食物摄入。
