雌二醇诱导大鼠的条件性味觉厌恶和位置厌恶：性别和剂量依赖性效应。

Estradiol-induced conditioned taste aversion and place aversion in rats: sex- and dose-dependent effects.

作者信息

de Beun R, Jansen E, Smeets M A, Niesing J, Slangen J L, van de Poll N E

机构信息

Netherlands Institute for Brain Research, Amsterdam.

出版信息

Physiol Behav. 1991 Nov;50(5):995-1000. doi: 10.1016/0031-9384(91)90427-p.

DOI:10.1016/0031-9384(91)90427-p

PMID:1805290

Abstract

Effects of various doses (0-250 micrograms/kg, SC) of estradiol-17 beta (E2) in a two-bottle choice conditioned taste aversion and a two-compartment conditioned place preference procedure were studied in male and female rats. Dose-dependent taste aversion and place aversion effects of E2 were established, and the conditioned taste aversion procedure was found to be more sensitive in detecting aversive properties of E2 than the conditioned place preference procedure. Although aversive properties of E2 were found in both sexes, the effects were clearly more prominent in males as compared to females. From this study, it was concluded that E2 acts as an unconditioned aversive stimulus in both male and female rats capable of gaining control over different types of behavior by associative learning.

摘要

在雄性和雌性大鼠中，研究了不同剂量（0 - 250微克/千克，皮下注射）的17β-雌二醇（E2）在双瓶选择条件性味觉厌恶和双室条件性位置偏爱实验中的作用。确定了E2的剂量依赖性味觉厌恶和位置厌恶效应，并且发现条件性味觉厌恶实验在检测E2的厌恶特性方面比条件性位置偏爱实验更敏感。虽然在两性中均发现了E2的厌恶特性，但与雌性相比，雄性中的效应明显更显著。从这项研究得出的结论是，E2在雄性和雌性大鼠中均作为一种非条件性厌恶刺激，能够通过联想学习对不同类型的行为产生控制作用。