Ganesan R, Simpkins J W
Department of Pharmacodynamics, University of Florida, Gainesville 32610.
Physiol Behav. 1990 Nov;48(5):647-52. doi: 10.1016/0031-9384(90)90205-i.
In three experiments, ovariectomized rats were given a familiar or novel diet prior to treatment with a brain-enhanced estradiol-chemical delivery system (E2-CDS, 1 mg/kg). Experiment 1 showed that food intake was suppressed in subjects receiving either diet, but animals given a novel diet initially showed a profound anorexia which eventually recovered to the moderate suppression of animals given the familiar diet. In Experiment 2, rats showed an aversion to a novel diet paired with the E2-CDS in a two-choice preference test given on Day 2 after the injection, indicating that the initial large reduction in intake was mediated by a conditioned taste aversion. However, no aversion was observed seven days after the E2-CDS, suggesting that the residual intake suppression was mediated by unconditioned aversion or appetite suppression. Experiment 3 showed that lengthening the postovariectomy time resulted in a taste aversion that persisted for a longer duration.
在三项实验中，对卵巢切除的大鼠在使用脑增强雌二醇化学递送系统（E2-CDS，1毫克/千克）进行治疗之前给予熟悉或新颖的饮食。实验1表明，接受任何一种饮食的受试动物的食物摄入量均受到抑制，但给予新颖饮食的动物最初表现出严重的厌食症，最终恢复到给予熟悉饮食的动物的中等抑制水平。在实验2中，大鼠在注射后第2天进行的双选偏好测试中表现出对与E2-CDS配对的新颖饮食的厌恶，这表明最初摄入量的大幅减少是由条件性味觉厌恶介导的。然而，在给予E2-CDS七天后未观察到厌恶，这表明残余的摄入量抑制是由非条件性厌恶或食欲抑制介导的。实验3表明，延长卵巢切除术后的时间会导致味觉厌恶持续更长时间。
