Kopferschmitt-Kubler M C, Pauli G
Service de Pneumologie, C.H.R.U., Strasbourg.
Rev Pneumol Clin. 1991;47(4):171-6.
The authors describe the methodology of allergen challenge tests, with special attention to some particular aspects, such as the allergenic extracts and their biological activity, and the methods used in aerosol administration and in measurements of bronchial obstruction. They present the results of their personal experience, concerning interindividual variations in a sensitized population and the reproducibility of the immediate reaction revealed by dose-response curves. Comparisons of allergen tests with exposure to allergens under physiological conditions are discussed. In occupational asthma the exposure tests sometimes constitute the only diagnostic method, owing to ignorance of the responsible mechanisms and to the multiplicity of incriminated substances. However, these tests are not without danger and must be performed by well-trained medical and paramedical teams.
作者描述了变应原激发试验的方法，特别关注了一些特定方面，如变应原提取物及其生物活性，以及气雾剂给药和支气管阻塞测量中使用的方法。他们展示了个人经验的结果，涉及致敏人群中的个体差异以及剂量反应曲线所显示的速发反应的可重复性。文中还讨论了变应原试验与生理条件下接触变应原的比较。在职业性哮喘中，由于对致病机制的无知以及涉案物质的多样性，接触试验有时是唯一的诊断方法。然而，这些试验并非没有风险，必须由训练有素的医疗和辅助医疗团队进行。
