通过一锅法四组分反应实现γ-内酰胺的非对映选择性合成。
Diastereoselective synthesis of gamma-lactams by a one-pot, four-component reaction.
作者信息
Wei Jingqiang, Shaw Jared T
机构信息
Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.
出版信息
Org Lett. 2007 Sep 27;9(20):4077-80. doi: 10.1021/ol701911u. Epub 2007 Aug 31.
PMID:17760458
Abstract
A new one-pot, four-component reaction (4CR) between amines, maleic anhydrides, aldehydes, and thiols has been discovered to form tetra- and pentasubstituted gamma-lactams with high diastereoselectivity. Each component is independently variable and employed in equivalent stoichiometry, producing only water as a byproduct.
摘要
人们发现，胺、马来酸酐、醛和硫醇之间可发生一种新型的一锅四组分反应（4CR），以高非对映选择性生成四取代和五取代的γ-内酰胺。各组分可独立变化，并以等化学计量比使用，仅产生水作为副产物。
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