Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Org Lett. 2010 Nov 19;12(22):5154-7. doi: 10.1021/ol102148b. Epub 2010 Oct 27.
An efficient one-pot asymmetric synthesis of highly substituted γ-lactams containing α-methylene groups has been successfully developed. A wide range of γ-lactams could be obtained in high yields with excellent diastereomeric ratios of up to 99:1 in favor of trans isomers. In particular, excellent enantioselectivities of the two newly formed stereogenic centers with up to 99% ee were observed.
已成功开发出一种高效的一锅不对称合成方法，用于合成含有α-亚甲基的高取代γ-内酰胺。该方法可以高收率得到多种γ-内酰胺，非对映选择性高达 99:1，有利于反式异构体。特别是，两个新形成的手性中心具有高达 99%ee 的对映选择性。
