Png Zhuang Mao, Cabrera-Pardo Jaime R, Peiró Cadahía Jorge, Gaunt Matthew J
Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge , UK . Email:
Chem Sci. 2018 Jul 31;9(39):7628-7633. doi: 10.1039/c8sc02855a. eCollection 2018 Oct 21.
A palladium(ii)-catalysed C(sp)-H carbonylation of free(NH) secondary aliphatic amines to 2-pyrrolidinones is described. A correlation between the nature of the carboxylate ligand and the diastereoselectivity and yield of the process was observed. As such, under these optimal conditions a range of aliphatic amines were converted to the corresponding trans-4,5-disubstituted 2-pyrrolidines with good d.r. and yield.
本文描述了钯（II）催化游离（NH）仲脂肪胺的C（sp）-H羰基化反应生成2-吡咯烷酮。观察到羧酸酯配体的性质与该反应的非对映选择性和产率之间存在相关性。因此，在这些最佳条件下，一系列脂肪胺以良好的非对映体比例和产率转化为相应的反式-4,5-二取代2-吡咯烷。
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