Gelb Michael H
Department of Chemistry, University of Washington, Seattle, WA 98195, USA.
Curr Opin Chem Biol. 2007 Aug;11(4):440-5. doi: 10.1016/j.cbpa.2007.05.038.
The prevalence of resistance to known antimalarial drugs has resulted in the expansion of antimalarial drug discovery efforts. Academic and nonprofit institutions are partnering with the pharmaceutical industry to develop new antimalarial drugs. Several new antimalarial agents are undergoing clinical trials, mainly those resurrected from previous antimalarial drug discovery programs. Novel antimalarials are being advanced through the drug development process, of course, with the anticipated high failure rate typical of drug discovery. Many of these are summarized in this review. Mechanisms for funding antimalarial drug discovery and genomic information to aid drug target selection have never been better. It remains to be seen whether ongoing efforts will be sufficient for reducing malaria burden in the developing world.
对已知抗疟药物产生耐药性的情况日益普遍,这促使人们加大了抗疟药物研发的力度。学术机构和非营利组织正与制药行业合作,共同开发新型抗疟药物。几种新型抗疟药物正在进行临床试验,主要是那些从以往抗疟药物研发项目中重新启用的药物。当然,新型抗疟药物正沿着药物研发流程推进,而药物研发通常有着预期的高失败率。本文综述了其中许多药物。资助抗疟药物研发的机制以及有助于药物靶点选择的基因组信息,目前处于最佳状态。目前仍有待观察,正在进行的这些努力是否足以减轻发展中世界的疟疾负担。