Travis C C, Bowers J C
Risk Analysis Section, Oak Ridge National Laboratory, Tennessee 37831.
Toxicol Ind Health. 1991 Jul;7(4):249-60. doi: 10.1177/074823379100700402.
Anesthetic potency data for 11 volatile anesthetics were correlated against body weight in multiple mammalian species, including man. The results indicate that the alveolar concentration necessary to produce anesthesia is approximately constant across species. Because alveolar ventilation rates scale with the 0.75 power of body weight, this implies that administered dose measured in mg/kg0.75/day produces the same anesthetic effect in all species. This analysis provides further support for the use of a mg/kg0.75/day interspecies scaling metric for acute toxic effects.
针对包括人类在内的多种哺乳动物物种，将11种挥发性麻醉剂的麻醉效能数据与体重进行了关联分析。结果表明，产生麻醉所需的肺泡浓度在不同物种间大致恒定。由于肺泡通气率与体重的0.75次幂成比例，这意味着以mg/kg0.75/天为单位计量的给药剂量在所有物种中产生相同的麻醉效果。该分析为使用mg/kg0.75/天的种间缩放指标来评估急性毒性作用提供了进一步支持。
