Deumer J, de Haan F, Tulp M T, van den Hoven R
Vet Rec. 1991 Nov 9;129(19):427-9. doi: 10.1136/vr.129.19.427.
The effects of an oral isoxsuprine-resin preparation on the blood flow in the thoracic limb of seven horses was determined by thermography. Treatment with the oral resin preparation resulted in increased skin temperatures compared with the non-medicated controls. The maximal temperature differences, 2.2 degrees C for the horses treated with 0.9 mg/kg and 1.8 degrees C for the horses treated with 1.2 mg/kg, occurred four hours after dosing. Plasma total isoxsuprine, determined in three horses, was detectable two hours after oral dosing and maximal eight hours after dosing, but free isoxsuprine could not be detected. Receptor binding studies demonstrated strong alpha-receptor binding, and this binding was so strong that even at isoxsuprine concentrations below the detection level receptors could have been stimulated.
通过热成像法测定了口服异克舒令树脂制剂对7匹马胸肢血流的影响。与未用药的对照组相比，口服树脂制剂治疗导致皮肤温度升高。给药后4小时出现最大温差，0.9毫克/千克治疗的马为2.2摄氏度，1.2毫克/千克治疗的马为1.8摄氏度。在3匹马中测定的血浆总异克舒令，口服给药后2小时可检测到，给药后8小时达到最大值，但未检测到游离异克舒令。受体结合研究表明存在强α受体结合，且这种结合非常强，以至于即使在异克舒令浓度低于检测水平时，受体也可能受到刺激。
