Harkins J D, Mundy G D, Stanley S, Woods W E, Sams R A, Richardson D R, Grambow S C, Tobin T
Maxwell H. Gluck Equine Research Center and the Department of Veterinary Science, University of Kentucky, Lexington 40506, USA.
Equine Vet J. 1998 Jul;30(4):294-9. doi: 10.1111/j.2042-3306.1998.tb04100.x.
Isoxsuprine is reported to be a peripheral vasodilator used in human and veterinary medicine to treat ischaemic vascular disease. In horses, it is generally administered orally to treat navicular disease and other lower limb problems. To define the scope and duration of its pharmacological responses after oral administration, 6 horses were dosed with isoxsuprine HCl (1.2 mg/kg bwt) q. 12 h for 8 days and then tested to assess the duration and extent of pharmacological actions. There was no significant difference between isoxsuprine and control treatment values for heart rate, spontaneous activity, sweat production, anal muscle tone, core and skin temperatures, and cutaneous blood flow. The lack of pharmacological effect following oral administration was in sharp contrast to the marked response following i.v. dosing reported in earlier experiments.
据报道，异克舒令是一种外周血管扩张剂，用于人类和兽医学治疗缺血性血管疾病。在马中，通常口服给药以治疗舟状骨病和其他下肢问题。为了确定口服给药后其药理反应的范围和持续时间，对6匹马每12小时口服盐酸异克舒令（1.2mg/kg体重），持续8天，然后进行测试以评估药理作用的持续时间和程度。异克舒令与对照处理在心率、自发活动、出汗、肛门肌张力、核心温度和皮肤温度以及皮肤血流量方面的值无显著差异。口服给药后缺乏药理作用与早期实验中静脉给药后明显的反应形成鲜明对比。
