Comparison of the metabolism of four sulphonamides between humans and pigs.
作者信息
Vree T B, Beneken Kolmer E W, Peeters A
机构信息
Department of Clinical Pharmacy, Academic Hospital Nijmegen Sint Radboud, The Netherlands.
出版信息
Vet Q. 1991 Oct;13(4):236-40. doi: 10.1080/01652176.1991.9694314.
PMID:1776238
Abstract
Pigs are unable to form N1-glucuronides of sulphadimethoxine and sulphamethomidine, while humans are able to do so. Pigs and humans are able to oxidise sulphapyridine and form the O-glucuronide. The double conjugate N4-acetylsulphapyridine-O-glucuronide is formed in humans but not in pigs. Sulphadiazine is mainly acetylated in both humans and pigs. A hypothesis about N1-glucuronidation is presented.
摘要
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