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Novel oxidative pathways of sulphapyridine and sulphadiazine by the turtle Pseudemys scripta elegans.

作者信息

Vree T B, Vree J B, Beneken Kolmer E W, Hekster Y A

机构信息

Department of Clinical Pharmacy, Academic Hospital Nijmegen Sint Radboud, The Netherlands.

出版信息

Vet Q. 1991 Oct;13(4):218-24. doi: 10.1080/01652176.1991.9694311.

DOI:10.1080/01652176.1991.9694311
PMID:1776236
Abstract

The sulphonamides sulphapyridine and sulphadiazine show novel hydroxy metabolites in the turtle Pseudemys scripta elegans. In the excreta of the turtles the monohydroxy metabolites 4-hydroxy- and 5-hydroxysulphapyridine and the dihydroxy metabolite 4,5-dihydroxysulphapyridine were detected. Of sulphadiazine only dihydroxy metabolites 4,5- and 4,6-dihydroxysulphadiazine were detected. About 70-90% of the dose of sulphapyridine was recovered, while this figure varied between 48 and 69% for sulphadiazine.

摘要

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