抗痴呆药物与啮齿动物海马依赖性记忆
Anti-dementia drugs and hippocampal-dependent memory in rodents.
作者信息
Yuede Carla M, Dong Hongxin, Csernansky John G
机构信息
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA.
出版信息
Behav Pharmacol. 2007 Sep;18(5-6):347-63. doi: 10.1097/FBP.0b013e3282da278d.
Abstract
Abnormalities in hippocampal structure and function are characteristics of early Alzheimer's disease (AD). Behavioral tests measuring hippocampal-dependent memory in rodents are often used to evaluate novel treatments for AD and other dementias. In this study, we review the effects of drugs marketed for the treatment of AD, such as the acetylcholinesterase inhibitors, donepezil, rivastigmine, galantamine and the N-methyl-D-aspartic acid antagonist, memantine, in rodent models of memory impairment. We also briefly describe the effects of novel treatments for cognitive impairment in rodent models of memory impairment, and discuss issues concerning the selection of the animal model and behavioral tests. Suggestions for future research are offered.
摘要
海马体结构和功能异常是早期阿尔茨海默病（AD）的特征。测量啮齿动物海马体依赖性记忆的行为测试常被用于评估AD和其他痴呆症的新疗法。在本研究中，我们回顾了用于治疗AD的上市药物，如乙酰胆碱酯酶抑制剂多奈哌齐、卡巴拉汀、加兰他敏以及N-甲基-D-天冬氨酸拮抗剂美金刚，在记忆损伤啮齿动物模型中的作用。我们还简要描述了记忆损伤啮齿动物模型中认知障碍新疗法的作用，并讨论了有关动物模型选择和行为测试的问题。最后给出了对未来研究的建议。
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