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APP/PS1小鼠学习策略选择与物体位置记忆损伤的差异

Differences in Learning Strategy Selection and Object Location Memory Impairments in APP/PS1 Mice.

作者信息

Jang Yoon-Sun, Kim Dong-Hee, Jeon Won Kyung, Han Jung-Soo

机构信息

Department of Biological Sciences, Konkuk University, Seoul 05029, Korea.

KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea.

出版信息

Exp Neurobiol. 2025 Aug 31;34(4):156-167. doi: 10.5607/en25013.

DOI:10.5607/en25013
PMID:40925884
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12426418/
Abstract

This study investigated the learning strategy preferences of 11-month-old APP/PS1 double transgenic (Tg) mice, a well-established murine model of Alzheimer's disease (AD). APP/PS1 Tg and non-Tg control mice were serially trained in visual and hidden platform tasks in the Morris water maze. APP/PS1 Tg mice performed poorly in visual platform training compared with non-Tg mice but performed as well as non-Tg mice in hidden platform training. Further analysis of their search paths for locating a hidden platform revealed that APP/PS1 Tg mice used more cued/response search patterns than place/spatial search patterns compared with non-Tg mice. Three months later, the object/location recognition memory of APP/PS1 Tg mice was assessed. Although their object recognition memory was intact, their object location memory was impaired. Neuropathological AD features of APP/PS1 transgenic mice were observed in the medial prefrontal cortex, retrosplenial cortex, and hippocampus, key brain regions involved in learning strategy shifts and spatial cognition. These results indicate that distinct search patterns and spatial memory deficits in APP/PS1 Tg mice are key features of AD animal models.

摘要

本研究调查了11月龄APP/PS1双转基因（Tg）小鼠（一种成熟的阿尔茨海默病（AD）小鼠模型）的学习策略偏好。APP/PS1 Tg小鼠和非Tg对照小鼠在莫里斯水迷宫中接受视觉和隐藏平台任务的系列训练。与非Tg小鼠相比，APP/PS1 Tg小鼠在视觉平台训练中表现较差，但在隐藏平台训练中的表现与非Tg小鼠相当。对它们寻找隐藏平台的搜索路径进行进一步分析发现，与非Tg小鼠相比，APP/PS1 Tg小鼠使用更多的线索/反应搜索模式而非位置/空间搜索模式。三个月后，评估了APP/PS1 Tg小鼠的物体/位置识别记忆。虽然它们的物体识别记忆完好无损，但物体位置记忆受损。在腹内侧前额叶皮质、压后皮质和海马体（参与学习策略转变和空间认知的关键脑区）中观察到了APP/PS1转基因小鼠的神经病理学AD特征。这些结果表明，APP/PS1 Tg小鼠独特的搜索模式和空间记忆缺陷是AD动物模型的关键特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d392/12426418/ffc22e19a184/en-34-4-156-f5.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d392/12426418/ffc22e19a184/en-34-4-156-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d392/12426418/13102b926350/en-34-4-156-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d392/12426418/2e4ef5843249/en-34-4-156-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d392/12426418/5cd5d5a3ad13/en-34-4-156-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d392/12426418/ca8b22868c2c/en-34-4-156-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d392/12426418/ffc22e19a184/en-34-4-156-f5.jpg

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本文引用的文献

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在 Morris 水迷宫中对 Tg4-42 阿尔茨海默病小鼠的搜索策略分析显示出早期的空间导航缺陷。
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