Sleijfer Stefan, Seynaeve Caroline, Verweij Jaap
Department of Medical Oncology, Erasmus University Medical Centre, Daniel den Hoed Cancer Centre, Rotterdam, The Netherlands.
Curr Opin Oncol. 2007 Sep;19(5):492-6. doi: 10.1097/CCO.0b013e3282748eaa.
To review gynaecological sarcomas, their management and future perspectives.
Soft tissue sarcomas are a group of tumours consisting of a wide variety of subtypes. The most common subtypes encountered in the female tract are uterine leiomyosarcomas and endometrial stromal sarcomas. Other subtypes do occur but at a much lower frequency. Mixed Müllerian tumours were previously considered to be a subtype of sarcoma, but recent evidence has revealed that they should in fact be regarded as carcinomas. Given the different approaches for different subtypes of sarcomas, their rarity and the complexity of treatment, the management of patients with gynaecological sarcomas should be delivered by multidisciplinary teams experienced in the treatment of these entities.
Gynaecological sarcomas are rare tumours and are treated differently from gynaecological carcinomas. Hopefully, improved insight into the pathogenesis of gynaecological sarcomas will yield novel therapies in the near future.
回顾妇科肉瘤、其治疗方法及未来展望。
软组织肉瘤是一组包含多种亚型的肿瘤。女性生殖道中最常见的亚型是子宫平滑肌肉瘤和子宫内膜间质肉瘤。其他亚型确实存在,但发生率要低得多。混合性苗勒管肿瘤以前被认为是肉瘤的一种亚型,但最近的证据表明它们实际上应被视为癌。鉴于肉瘤不同亚型的治疗方法不同、其罕见性以及治疗的复杂性,妇科肉瘤患者的管理应由在这些疾病治疗方面经验丰富的多学科团队来进行。
妇科肉瘤是罕见肿瘤,其治疗方法与妇科癌不同。有望在不久的将来,对妇科肉瘤发病机制的深入了解能带来新的治疗方法。