McCarthy Jane
South London & Maudsley NHS Foundation Trust, London, UK.
Curr Opin Psychiatry. 2007 Sep;20(5):472-6. doi: 10.1097/YCO.0b013e32821f6095.
The present article reviews the increasing literature on comorbidity, treatment and use of health service resources for children and adolescents with autism spectrum disorders and intellectual disability from January 2006 to January 2007.
Children and adolescents with autism spectrum disorders and intellectual disability have a high prevalence of attention-deficit/hyperactive disorder, mood disorders, catatonia and repetitive behaviours compared with children without autism. Psychopharmacology is effective in reducing symptoms of behavioural problems and attention-deficit/hyperactive disorder, although further studies are required. Autism spectrum disorders are recognized to occur with Smith-Lemli-Optiz syndrome and 22q11.2 deletion syndrome. Children and adolescents with autism spectrum disorders have a high use of mental health services.
There is increasing evidence of the comorbidity of psychiatric and behavioural disorders in young people with autism spectrum disorders and intellectual disability responding to established treatments. This high morbidity results in increased healthcare expenditure compared with children without autism and intellectual disability.
本文回顾了2006年1月至2007年1月期间,关于自闭症谱系障碍和智力残疾儿童及青少年的共病、治疗以及卫生服务资源利用情况的文献日益增多。
与无自闭症的儿童相比,自闭症谱系障碍和智力残疾儿童及青少年中,注意力缺陷/多动障碍、情绪障碍、紧张症和重复行为的患病率较高。尽管还需要进一步研究,但精神药理学在减轻行为问题和注意力缺陷/多动障碍症状方面是有效的。自闭症谱系障碍被认为与史密斯-勒米-奥皮兹综合征和22q11.2缺失综合征同时发生。自闭症谱系障碍儿童及青少年对心理健康服务的利用率很高。
越来越多的证据表明,自闭症谱系障碍和智力残疾的年轻人中,精神和行为障碍共病,且对既定治疗有反应。与无自闭症和智力残疾的儿童相比,这种高发病率导致医疗保健支出增加。