Bertelli Marco O, Bianco Annamaria, Deb Shoumitro, Scuticchio Daniela, Kaleci Shaniko, Scattoni Maria Luisa
CREA (Research and Clinical Centre), Fondazione San Sebastiano, Misericordia di Firenze, Florence, Italy.
SIDiN, Italian Society for Neurodevelopmental Disorders, Florence, Italy.
Front Psychiatry. 2024 Aug 28;15:1447262. doi: 10.3389/fpsyt.2024.1447262. eCollection 2024.
Despite increasing evidence of high psychopathological vulnerability in people with Autism Spectrum Disorder (ASD) and/or Intellectual disability (ID), comprehensive data on prevalence and presentation of psychiatric disorders (PD) in people with significant cognitive and communication impairment are lacking. The extent to which PD can present with behavioral/observable symptoms and include Problem Behaviors (PB) has also been scarcely evaluated through population-based studies. The paper presents the protocol of a cross-sectional study aimed at filling these gaps, referred to a large multicentric Italian population-based sample of adolescents and adults.
A battery of validated scales, SPAIDD, DASH-II, DiBAS-R, and STA-DI, is used to support and control for clinical diagnoses of PD. Study population is stratified according to different independent variables such as the severity of ID and ASD, gender, age group, and source of recruitment. A network analysis will be carried out to identify the most central behavioral symptoms for the various PD and their relationship with PB. Overlap between psychiatric symptoms and ASD and ID phenotypes is also addressed.
This study should provide valuable insight into better diagnostic accuracy, leading to well-informed interventions to improve the quality of life of people with ASD and/or ID.
尽管越来越多的证据表明自闭症谱系障碍（ASD）和/或智力残疾（ID）患者存在较高的精神病理学易感性，但缺乏关于存在显著认知和沟通障碍的人群中精神障碍（PD）患病率及表现的全面数据。基于人群的研究也很少评估PD在行为/可观察症状方面的表现以及是否包括问题行为（PB）。本文介绍了一项横断面研究的方案，该研究旨在填补这些空白，研究对象为意大利一个基于人群的大型多中心青少年和成人样本。
使用一系列经过验证的量表，即SPAIDD、DASH-II、DiBAS-R和STA-DI，来辅助和控制PD的临床诊断。研究人群根据不同的自变量进行分层，如ID和ASD的严重程度、性别、年龄组以及招募来源。将进行网络分析，以确定各种PD最核心的行为症状及其与PB的关系。还将探讨精神症状与ASD和ID表型之间的重叠情况。
本研究应能为提高诊断准确性提供有价值的见解，从而为改善ASD和/或ID患者的生活质量提供明智的干预措施。
