Lai Timothy Y Y, Lai Ricky Y K, Ngai Jasmine W S, Chan Wai-Man, Li Haitao, Lam Dennis S C
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong, People's Republic of China.
Doc Ophthalmol. 2008 Jan;116(1):29-40. doi: 10.1007/s10633-007-9075-8. Epub 2007 Aug 29.
To evaluate the first and second-order kernel multifocal electroretinogram (mfERG) response abnormalities in patients with acute central serous chorioretinopathy (CSC).
This was a cross-sectional observational study in which 45 eyes of 45 patients with acute CSC underwent mfERG recordings. Peak amplitudes and implicit times of the first and second-order kernel responses were analyzed and compared with 20 age-matched normal controls. Correlation analyses were performed between the patients' visual acuity and the first and second-order amplitudes and implicit times.
The first-order N1 and P1 mfERG amplitudes in the central three concentric rings were reduced in eyes with acute CSC compared with controls (P < 0.05). The first-order P1 implicit times of the central four rings were also delayed (P < 0.05). For the second-order mfERG response, there were significant reductions in the second-order P1 and N1 amplitudes in rings 3-5 compared with controls (P < 0.05). No significant difference between the second-order P1 and N1 implicit times was found compared with controls (P > 0.05). Correlation analyses showed significant correlations between visual acuity and the first-order N1 response amplitudes of rings 1 and 2, and for the first-order N1 and P1 implicit times of rings 1-4 (P < 0.05).
Both first and second-order mfERG response abnormalities occur in eyes with acute CSC. These results suggest that in acute CSC, while outer retinal dysfunction is mostly localized to the central macula, there might be more widespread impairment in adaptive mechanisms of the inner retina or outer plexiform layer dysfunction in the more peripheral macula.
评估急性中心性浆液性脉络膜视网膜病变（CSC）患者一阶和二阶内核多焦视网膜电图（mfERG）反应异常情况。
这是一项横断面观察性研究，对45例急性CSC患者的45只眼进行mfERG记录。分析一阶和二阶内核反应的峰值振幅和隐含时间，并与20名年龄匹配的正常对照者进行比较。对患者的视力与一阶和二阶振幅及隐含时间进行相关性分析。
与对照组相比，急性CSC患者眼中中央三个同心环的一阶mfERG的N1和P1振幅降低（P<0.05）。中央四个环的一阶P1隐含时间也延迟（P<0.05）。对于二阶mfERG反应，与对照组相比，第3至5环的二阶P1和N1振幅显著降低（P<0.05）。与对照组相比，二阶P1和N1隐含时间未发现显著差异（P>0.05）。相关性分析显示，视力与第1和2环的一阶N1反应振幅之间，以及与第1至4环的一阶N1和P1隐含时间之间存在显著相关性（P<0.05）。
急性CSC患者眼中一阶和二阶mfERG反应均出现异常。这些结果表明，在急性CSC中，虽然外层视网膜功能障碍大多局限于中央黄斑，但可能在内层视网膜适应机制或周边黄斑外层神经丛层功能障碍方面存在更广泛的损害。
