安非他酮单独使用及与尼古丁口香糖联合使用的疗效。
Efficacy of bupropion alone and in combination with nicotine gum.
作者信息
Piper Megan E, Federman E Belle, McCarthy Danielle E, Bolt Daniel M, Smith Stevens S, Fiore Michael C, Baker Timothy B
机构信息
University of Wisconsin School of Medicine and Public Health, Center for Tobacco Research and Intervention, Madison, WI 53711, USA.
出版信息
Nicotine Tob Res. 2007 Sep;9(9):947-54. doi: 10.1080/14622200701540820.
Abstract
In this double-blind, placebo-controlled smoking cessation treatment study, 608 participants were randomly assigned to receive active bupropion and active 4-mg gum (AA, n = 228), active bupropion and placebo gum (AP, n = 224), or placebo bupropion and placebo gum (PP, n = 156). Relative to the PP group, the AA and AP groups were each significantly more likely to be abstinent at 1 week, end of treatment, and 6 months but not at 12 months postquit. After the first week postquit there were no differences in abstinence rates between the AA and AP groups. We found no significant individual difference variables that moderated outcome beyond 1 week postquit.
摘要
在这项双盲、安慰剂对照的戒烟治疗研究中，608名参与者被随机分配接受活性安非他酮和4毫克活性口香糖（AA组，n = 228）、活性安非他酮和安慰剂口香糖（AP组，n = 224）或安慰剂安非他酮和安慰剂口香糖（PP组，n = 156）。与PP组相比，AA组和AP组在戒烟1周、治疗结束时和6个月时持续戒烟的可能性均显著更高，但在戒烟后12个月时并非如此。在戒烟后第一周，AA组和AP组的持续戒烟率没有差异。我们发现，在戒烟1周后，没有显著的个体差异变量能够调节结果。
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