Brurberg Kjetil G, Benjaminsen Ilana C, Dørum Liv M R, Rofstad Einar K
Group of Radiation Biology and Tumor Physiology, Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway.
Magn Reson Med. 2007 Sep;58(3):473-81. doi: 10.1002/mrm.21367.
Temporal heterogeneity in blood perfusion is a common phenomenon in tumors, but data characterizing the nature of the blood flow fluctuations are sparse. This study investigated the occurrence of blood flow fluctuations in A-07 melanoma xenografts by using gadopentetate dimeglumine (Gd-DTPA)-based dynamic contrast-enhanced MRI (DCE-MRI). Each tumor was subjected to two DCE-MRI acquisitions separated by 1 hour. The data were processed by Kety analysis and resulted in two E.F images (E is the initial extraction fraction of Gd-DTPA and F is the perfusion) and two lambda images (lambda is the partition coefficient of Gd-DTPA) for each tumor. The E . F images were used to determine the changes in blood perfusion arising in the time between the two imaging sequences. The lambda images were used to control the reproducibility of the experimental procedure. The study showed that DCE-MRI with subsequent Kety analysis is a useful method for detection of blood flow fluctuations in A-07 tumors, and strongly suggested that the peripheral regions of A-07 tumors are more exposed to temporal changes in blood perfusion than are the central regions.
血液灌注的时间异质性是肿瘤中的常见现象，但表征血流波动性质的数据却很稀少。本研究通过使用基于钆喷酸葡胺（Gd-DTPA）的动态对比增强磁共振成像（DCE-MRI），研究了A-07黑色素瘤异种移植瘤中血流波动的发生情况。每个肿瘤均接受两次间隔1小时的DCE-MRI采集。数据通过凯氏分析进行处理，每个肿瘤得到两张E.F图像（E为Gd-DTPA的初始提取分数，F为灌注）和两张λ图像（λ为Gd-DTPA的分配系数）。E.F图像用于确定两次成像序列之间的时间内出现的血液灌注变化。λ图像用于控制实验过程的可重复性。该研究表明，后续进行凯氏分析的DCE-MRI是检测A-07肿瘤中血流波动的有用方法，并强烈提示A-07肿瘤的周边区域比中心区域更容易受到血液灌注时间变化的影响。
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