老年高血压患者在静脉持续输注咪达唑仑镇静下拔牙过程中的血压变化
Blood pressure changes of elderly hypertensive patients during dental extraction under sedation with continuous intravenous infusion of midazolam.
作者信息
Zhao Ji-Zhi, Wan Kuo, Jing Quan, Chen Xi
机构信息
Department of Stomatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730.
出版信息
Chin Med Sci J. 2007 Jun;22(2):132-5.
OBJECTIVE
To evaluate the changes in blood pressure (BP) of elderly hypertensive patients having dental extraction under sedation with continuous intravenous infusion of midazolam.
METHODS
One hundred elderly hypertensive patients undergoing dental extraction were recruited for this single-blind, randomized, controlled study. Patients in intervention group (n = 50) were given midazolam dissolved in glucose solution and patients in control group (n = 50) were given glucose solution only with communication technique. Systolic BP (SBP) and diastolic BP (DBP) were recorded in five time points.
RESULTS
Under basal conditions, intervention group did not show significant difference in BP compared with control group. Before sedation, mean values of SBP and DBP (especially SBP) significantly increased compared with basal conditions in both groups (P < 0.05). During dental extraction sessions, mean values of BP in intervention group significantly decreased than control group (P < 0.05), but coefficient of variation did show significant difference in both groups.
CONCLUSION
Continuous intravenous infusion of midazolam has been proved to be very successful in controlling BP of elderly patients having dental extraction.
目的
评估老年高血压患者在静脉持续输注咪达唑仑镇静下行拔牙术时血压（BP）的变化。
方法
选取100例接受拔牙术的老年高血压患者进行这项单盲、随机对照研究。干预组（n = 50）患者给予溶于葡萄糖溶液的咪达唑仑，对照组（n = 50）患者仅给予葡萄糖溶液并采用沟通技巧。在五个时间点记录收缩压（SBP）和舒张压（DBP）。
结果
在基础状态下，干预组与对照组的血压无显著差异。镇静前，两组的SBP和DBP平均值（尤其是SBP）较基础状态均显著升高（P < 0.05）。在拔牙过程中，干预组的血压平均值较对照组显著降低（P < 0.05），但两组的变异系数无显著差异。
结论
静脉持续输注咪达唑仑已被证明在控制老年患者拔牙术时的血压方面非常成功。
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