Morvay K, Nawroth R, Szentléleki K, Török G, Senger H
II. Chirurgische Klinik, Medizinischen Semmelweis-Universität Budapest.
Zentralbl Chir. 1991;116(23):1359-67.
Because of the in a controversial way held discussion on an possibly existing connection between bile acid metabolism and the development of colonic carcinomas experimental researches on this problems were carried out with Wistar rats. Two test series with altogether 130 animals manifested independently from each other the result of a provable connection. During model tests small bowel resections and colon exclusion operations were realized. The carcinoma protection was accomplished by 1.2 dimethylhydrazine administered for 14 weeks in a doses of 20 mg/kg body weight. The carcinoma was proved after a 32-weeks-period. It was shown that in case of shortening the ileum more than in case of reduction of the jejunum on the left-side colon adenocarcinomas develop and the amount of the excreted fecal bile acids is the highest one. In bypassing the left-side section of the colon carcinomas develop also on the left side of the colon. But their number is significantly lower than of those on the right side. The test results indicate a causal connection.
由于关于胆汁酸代谢与结肠癌发生之间可能存在的联系的讨论存在争议，因此对这个问题用Wistar大鼠进行了实验研究。两个共包含130只动物的试验系列彼此独立地显示出可证明的联系结果。在模型试验中，进行了小肠切除术和结肠排除手术。通过以20mg/kg体重的剂量给予1.2 - 二甲基肼14周来实现癌症预防。32周后证实发生了癌症。结果表明，在回肠缩短的情况下，左侧结肠腺癌的发生比空肠减少时更多，并且排泄的粪便胆汁酸量是最高的。在绕过结肠左侧部分时，结肠左侧也会发生癌症。但其数量明显低于右侧的癌症数量。试验结果表明存在因果关系。
