Eriksen L, Dahl-Petersen I, Haugaard S B, Dela F
Department of Biomedical Sciences, The Copenhagen Muscle Research Centre, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark.
Diabetologia. 2007 Nov;50(11):2245-53. doi: 10.1007/s00125-007-0783-0. Epub 2007 Sep 1.
AIMS/HYPOTHESIS: We evaluated and compared the effects on glycaemic control of two different exercise protocols in elderly men with type 2 diabetes mellitus.
Eighteen patients with type 2 diabetes mellitus carried out home-based bicycle training for 5 weeks. Patients were randomly assigned to one of two training programmes at 60% of maximal oxygen uptake: three 10 min sessions per day (3 x 10) or one 30 min session per day (1 x 30). Plasma insulin, C-peptide and glucose concentrations were measured during a 3 h oral glucose tolerance test (OGTT). Insulin sensitivity index (ISI(composite)), pre-hepatic insulin secretion rates (ISR) and change in insulin secretion per unit change in glucose concentrations (B(total)) were calculated.
Cardiorespiratory fitness increased in response to training in both groups. In group 3 x 10 (n = 9) fasting plasma glucose (p = 0.01), 120 min glucose OGTT (p = 0.04) and plasma glucose concentration areas under the curve at 120 min (p < 0.04) and 180 min (p = 0.07) decreased. These parameters remained unchanged in group 1 x 30 (n = 9). No significant changes were found in ISI(composite), ISR and B(total) in either of the exercise groups. In a matched time-control group (n = 10), glycaemic control did not change.
CONCLUSIONS/INTERPRETATION: Moderate to high-intensity training performed at 3 x 10 min/day is preferable to 1 x 30 min/day with regard to effects on glycaemic control. This is in spite of the fact that cardiorespiratory fitness increased similarly in both exercise groups. A possible explanation is that the energy expenditure associated with multiple short daily sessions may be greater than that in a single daily session.
目的/假设：我们评估并比较了两种不同运动方案对老年2型糖尿病男性患者血糖控制的影响。
18例2型糖尿病患者进行了为期5周的居家自行车训练。患者被随机分配到两个训练方案之一，运动强度为最大摄氧量的60%：每天3次，每次10分钟（3×10）或每天1次，每次30分钟（1×30）。在3小时口服葡萄糖耐量试验（OGTT）期间测量血浆胰岛素、C肽和葡萄糖浓度。计算胰岛素敏感性指数（ISI（综合））、肝前胰岛素分泌率（ISR）以及葡萄糖浓度每单位变化时胰岛素分泌的变化（B（总量））。
两组训练后心肺功能均有所提高。在3×10组（n = 9）中，空腹血糖（p = 0.01）、OGTT 120分钟血糖（p = 0.04）以及120分钟（p < 0.04）和180分钟（p = 0.07）时的血浆葡萄糖浓度曲线下面积均降低。这些参数在1×30组（n = 9）中保持不变。两个运动组的ISI（综合）、ISR和B（总量）均未发现显著变化。在匹配的时间对照组（n = 10）中，血糖控制没有变化。
结论/解读：就血糖控制效果而言，每天进行3次、每次10分钟的中高强度训练优于每天1次、每次30分钟的训练。尽管两个运动组的心肺功能提高程度相似。一个可能的解释是，每日多次短时间训练所消耗的能量可能大于单次长时间训练。
